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SAVERIO ROTA
We explore the integrability of the 1+1 dimensional massless Thirring Quantum Cellular Automaton, which describes the discrete-time evolution of fermionic modes on a lattice with local, number-preserving interactions. This interaction serves as a discrete-time analogue of those characterising integrable Hamiltonian systems such as the Thirring and Hubbard models. Motivated by this...
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Francesca Brero (Physics Department, University of Pavia and INFN, Pavia Section)
Magnetic nanoparticles (MNPs) are widely used in biomedical applications, including their role as hyperthermic agents for tumor treatment via Magnetic Fluid Hyperthermia (MFH) and as tracers in Quantitative Susceptibility Mapping (QSM).
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In MFH, MNPs exposed to an alternating magnetic field generate localized heat within pathological tissues, enabling targeted thermal therapy. QSM is an... -
SETAREH FATEMI (INFN)
The PNC-PNRR ANTHEM project aims at building a Boron Neutron Capture Therapy clinical facility in Caserta. A RFQ proton accelerator with 5 MeV Energy and 30 mA current will be coupled to a Beryllium target, thus obtaining neutrons with energy up to 3 MeV. Both the RFQ accelerator and the Be target have been designed and developed by the INFN Legnaro National Laboratories. Spoke 4, Pilot 4.9 of...
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Dr Hanan Ali (Università degli studi di Pavia)
We demonstrate that bound states in the continuum (BICs) can arise in plasmonic metasurfaces and enable a strong chiral optical response. The metasurface consists of a gold film on glass patterned with a square lattice of nanoholes whose shapes are deformed from circular to oval. Symmetry breaking induces a quasi-BIC in the absorption spectrum on the low-energy side of the...
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Prof. Vittorio Bellani (Dipartimento di Fisica “A. Volta” Università di Pavia and INFN, Pavia, Italy)
The MANIFOLD project (Multidimensional nANodevice archItectures For lOw-perturbation singLe ion Detection) introduces a cutting-edge detector for low-perturbation, high-resolution sensing of diluted H/He ion beams (100 keV–2 MeV). Using multiwalled carbon nanotubes (MWCNTs), it delivers submicrometric resolution with negligible beam disturbance.
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Ions or single particles traverse a MWCNT-lined... -
ILARIA VAI
CERN has developed several strategies to reduce the use and release of greenhouse gases (GHG), including environmentally friendly gas mixtures and recovery systems for detector exhaust. Among these gases, CF₄ plays a significant role, contributing about 20% of CERN’s direct GHG emissions. Building on this expertise, the CH₄ Livestock Emission (CH4rLiE) project—born as a spin-off of the CMS...
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MASSIMILIANO MALGIERI
Countering pseudoscientific misinformation is an important goal for outreach initiatives, especially when directed to young students. Quantum physics and quantum technology are especially prone to being communicated, intentionally or otherwise, in a deformed way which may induce severe misconceptions, make the public vulnerable to scams and deceptions, or even pave the way to anti-scientific...
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ANGELA ROSY MORGILLO, Davide Poderini (Department of Physics, University of Pavia)
Positive non-decomposable maps play a fundamental role in quantum information theory, as they provide a tool to detect entanglement beyond what is possible with decomposable maps.
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Despite their importance, relatively little is known about the structure of positive non-decomposable maps or systematic methods to generate them. In this work, we present a fully differentiable optimization... -
MASSIMO BORGHI
Quantum extreme learning machines (QELMs) are unconventional computing architectures that have shown strong potential for classical and quantum machine-learning tasks. However, the probabilistic nature of quantum measurements typically requires extensive experimental repetitions to accurately estimate expectation values, leading to severe trade-offs among acquisition time, experimental...
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ANDREA PIZZAMIGLIO
Quantum simulation aims to deepen our understanding of the physics of quantum systems with many constituents, whose analytical or numerical treatment on classical computers remains unattainable. Most quantum simulators are digital, evolving networks of qubits in discrete time steps; consequently, understanding discrete quantum dynamics is crucial for their development. When locality and...
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NICOLA MANENTI
The search for neutrinoless double beta decay (0νββ) is crucial for testing lepton-number violation, probing physics beyond the Standard Model, and determining whether neutrinos are Majorana particles. CUORE, a tonne-scale cryogenic experiment at LNGS, studies 0νββ in $^{130}$Te using 988 TeO$_2$ bolometers operated below 15 mK.
Since 2017, CUORE has collected over 2.5 tonne-years of...
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FRANCESCO FLORIS (Dipartimento di Fisica)
The detection of chiral properties via circular dichroism (CD) is attracting significant attention, with plasmonic metasurfaces providing essential signal enhancement through tailored symmetry breaking. This work reports the experimental characterization of the chiral optical response from a gold metasurface featuring asymmetric oval nanoholes, supporting both surface plasmon polariton (SPP)...
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ROSSELLA SEMERANO
Acute Lymphoblastic Leukemia (ALL) is commonly treated with L-Asparaginase (L-ASNase), a chemotherapy agent that exploits metabolic vulnerability in leukemic cells by depleting asparagine/glutamine, aminoacids required for their proliferation and survival. Single-cell-RNA sequencing (scRNAseq) is a high-throughput technique providing unprecedented insights into treatment response. In this...
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73. From Survival Curves to Isoeffective Dose: Radiobiological Modelling of BNCT Mixed-Field EffectsIAN POSTUMA
Boron$~$Neutron$~$Capture$~$Therapy$~$(BNCT)$~$delivers$~$tumor-selective high-LET damage through a mixed radiation field in which $^{10}$B(n,α)$^7$Li products coexist with photons and protons. At the University of Pavia, we integrate radiobiological experiments with detailed Monte Carlo dosimetry to improve mixed-field dose response modeling and strengthen the photon iso-effective dose...
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SARA CONGIA
Biphoton quantum frequency comb (BQFC) sources generate high-dimensional entangled states in the frequency domain and represent a powerful resource for quantum information processing. Their coherent manipulation requires frequency-bin processors capable of performing reconfigurable unitary operations on frequency bins with high fidelity and success probability. In this work, we present a fully...
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Dr Simone Restelli (Università di Pavia, Dipartimento di Fisica “A. Volta” and INFN, Pavia, Italy)
This study’s aim is to explore the use of Gallium Nitride (GaN) nanowires (NWs) for photoelectrochemical water splitting. GaN's wide bandgap may offer a route for hydrogen production using solar energy. However, growth challenges, such as high defect densities, hinder its efficiency. Nanowire structures offer a solution due to their low defect density and efficient strain relaxation. We grew...
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GIOVANNI CHESI (Università degli Studi di Pavia)
Quantum key distribution (QKD) protocols take at least two advantages from high-dimensional (HD) systems: the secret key rate scaling as the dimension and the opportunity of exploiting more than two mutually unbiased bases (MUBs). Indeed, if the dimension d of the system is a prime power, then d+1 MUBs exist. Here, we retrieve analytic key rates for a BBM92-like protocol, where the...
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CHIARA AIMÈ
The goal of precision physics is to perform extremely accurate and consistent measurements in order to test fundamental theories, understand the limits of current models, and search for new physics.
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In the standard model of particle physics, the masses of the carriers of the weak interaction, the W and Z bosons, are uniquely related, and a precise determination of their values is important... -
GIORGIO BAIOCCO
Understanding whether the unavoidable exposure to environmental radiation is necessary for maintaining proper functioning and stress-response capability in living organisms is an intriguing open question.
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The INFN-funded DISCOVER22 project investigated the immune response modulation in a below-background radiation environment exploiting the Laboratori Nazionali del Gran Sasso – LNGS... -
ALESSANDRO MENEGOLLI
The Department of Physics and the INFN Pavia Section are actively involved in the SBN-ICARUS and DUNE experiments, both based on liquid-argon time projection chamber (LAr-TPC) technology. The Short-Baseline Neutrino (SBN) program at Fermilab aims to precisely investigate anomalies in neutrino oscillations and to search for sterile neutrinos using a short-baseline beam. DUNE represents the next...
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Emanuele Romano, Massimo Rossella, Michele Pirola
Il Laboratorio di Servizio Elettronica beneficia della collaborazione di personale afferente all’INFN Sezione di Pavia, al Dipartimento di Fisica e al Centro Grandi Strumenti dell’Università di Pavia. Si dedica allo sviluppo di circuiti analogici, digitali e di potenza e al supporto di attività di ricerca locali, nazionali ed internazionali. È infatti inserito in un contesto di collaborazione...
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TOMMASO BRAMBILLA (Università di Pavia)
How can genuinely nonlocal quantum measurements emerge from strictly local operations? We address this question within the framework of Quantum Cellular Automata (QCAs), introducing Operational Measurement Protocols: simple procedures that alternate local measurements with the intrinsic time evolution of the system. Remarkably, these protocols reproduce the statistics of nonlocal measurements...
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MARTINA FORESTI
Valence tautomers (VTCs) undergo a reversible charge redistribution when subject to the variation of external thermodynamic parameters (e.g. temperature). Conversely, the electronic modification acts as a switch for the magnetic state of the compound.
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Here, we report on our experimental study of a cobalt-based VTC, [Co(Me2tpa)]2(diox-S-diox)(PF6)2·MeOH [1]. By means of SQUID magnetometry we... -
Dr MARGHERITA PORRU (Università degli Studi di Pavia and INFN sezione di Pavia)
Iron oxide-based magnetic nanoparticles (MNPs) are exploited as Contrast Agents (CAs) for Magnetic Resonance Imaging (MRI). The magnetic nature and high magnetization values induce sizable inhomogeneities in the local magnetic field, perturbing the surrounding hydrogen nuclei present in the biological tissues according to their bio-distribution. The perturbations at nuclear sites shorten the...
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MANUEL MARIANI
We present an investigation, through 1H NMR and SQUID magnetometry, of the effects on the magnetic properties of Mn12tBuAc single molecule magnet (SMM) crystals hit or not by alpha and beta particles, and gamma radiations. Measurements were performed at T=2.2K as a function of an external magnetic field applied parallel to the molecules easy axis. In NMR experiments, when the field is applied...
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Alessandro Bacchetta, LUCA POLANO (University of Pavia), MARCO RADICI (INFN - Sezione di Pavia)
The proton is the most common element of the visible universe, yet we
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don't know how to reconstruct its macroscopic properties (mass, spin,..)
from the elementary degrees of freedom of the Strong Interaction, the
quarks and gluons (collectively, partons) of QCD. Partons are not
visible, they are confined inside hadrons because at hadronic mass
scales QCD is highly nonlinear and not... -
RICCARDO ROSSINI (University of Pavia & INFN Pavia)
Muonic atoms are formed after the capture of negative muons in atomic orbitals, followed by de-excitation through the emission of characteristic X-rays. In high-Z atoms, nuclear capture can occur, producing gamma rays with energies strongly dependent on nuclear structure.
The FAMU experiment at RAL (UK) aims at measuring the ground-state hyperfine splitting in muonic hydrogen to extract the...
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GIOVANNI PELLEGRINI
In the last decade neural networks were introduced in many physics workflows with great promise, but after the initial enthusiasm, their limitations started to emerge. Now that the dust is settling, we aim to demonstrate their usefulness in a few specific applications. We explore the deployment of neural networks in two distinct domains: advanced imaging and inverse photonic design. In...
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PAOLO MARIA MONTAGNA
We present “PER me si va ne la fisica recente”, an educational escape room on particle physics designed by the Physics4Teenagers group to introduce secondary school students to concepts rarely addressed in formal curricula. The activity combines content-driven puzzles, narrative engagement, and structured debriefing, and has become a permanent installation at UniPV and INFN.
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The research... -
LUCA ZATTI
We present a team-based educational game, designed and developed in-house as part of the activities of the Physics4Teenagers group, aimed at upper secondary school classes and focused on issues related to the energy transition and environmental sustainability. We describe the educational objectives, the main physics concepts addressed, and the structure and implementation of the game,...
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Ms Agnese Robustelli Test (University of Pavia, INFN Pavia unit), Ms Martina Scagni (IRCCS Polyclinic San Matteo)
Medical image analysis provides a non-invasive framework to investigate disease-related imaging patterns. Our work focuses on radiomics applied to Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) data, extracting quantitative features to study their association with biomarker expression and with different disease phenotypes and subtypes. These approaches aim to complement...
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ANGELA ROSY MORGILLO, EMANUELE TUMBIOLO, Mr Simone Roncallo (Universita' di Pavia)
Visual information can be manipulated in terms of images, usually captured and then processed through a sequence of computational operations. Alternatively, optical systems can perform such operations directly, reducing computational overhead at the cost of stricter design requirements. We discuss this workflow in the context of quantum technologies. First, we introduce a quantum algorithm...
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Dr Giacomo Guarnieri (University of Pavia)
What is a quantum battery? Actually, it is not an ‘everyday-life battery’ that exploits some quantum features. Rather, we can call ‘quantum battery’ any quantum object capable of storing energy and delivering it when needed. However, such energy can be subjected to non-negligible fluctuations. This represents a remarkable problem: quantum computers, for instance, need a high level of precision...
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CECILIA RIANI
The IMAGEOMICS Project (co-funded by the European PIANOFORTE partnership) aims to improve the benefit/risk ratio of breast-cancer (BC) radiotherapy, focusing on immune system activation by radiation. A work-package is dedicated to the identification of molecular changes in the tumor micro-environment after radiation, using high-throughput Spatial-Omics techniques.
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To this aim, we will collect... -
PAOLO WALTER CATTANEO (INFN)
In the last years the experiment MEGII at PSI (Paul-Scherrer-Institut) in Switzerland has improved of two orders of magnitude the limit on the
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Lepton Flavor Violating decay mu->e gamma.
This decay is very sensitive to BSM (Beyond the Standard Model) physics.
In 2026 MEGII will complete the data taking reaching
a sensitivity down to BR(mu -> e gamma)<6 10^-14.
Because this decay remains... -
SUSANNA COSTANZA
Transverse-momentum dependent parton distributions (TMDs) are a key tool to explore the three-dimensional structure of hadrons in momentum space. Recent extractions of unpolarized quark TMDs in the nucleon have reached a theoretical accuracy comparable to that of collinear parton distribution functions, although their uncertainties remain significantly larger due to the limited size of the...
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GERALDINE GONON
In space, astronauts are exposed to a complex radiation field with charged particles and secondary neutrons causing detrimental biological effects through heterogeneous energy deposition.
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Within the ASI-funded n-SPACE project, neutron effects are investigated through in-vitro cell culture irradiations at CNAO, where high-energy protons striking an aluminum block, representative of... -
MADDALENA PATRINI
Thin films of polymers and their hybrid compounds are advancing rapidly due to their technological applications in electronics, photonics, and multidisciplinary nanotechnology. Characterization methods must be refined appropriately to obtain information and data useful in the design and analysis of devices. With this aim, the material-science approach has improved; therein, optical...
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RICCARDO SCAGLIONI (UniPV & INFN Pavia)
LHC entrerà nella sua fase ad Alta Luminosità (High-Luminosity LHC) nel 2030, con l’obiettivo di aumentare i dati raccolti di un intero ordine di grandezza. L’esperimento ATLAS ha in programma un significativo upgrade del sistema di Trigger e Acquisizione Dati (TDAQ) per far fronte alle nuove condizioni di lavoro. In questo contesto, il gruppo ATLAS di Pavia si occupa dell’upgrade di uno dei...
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LEONARDO LONATI
L-Asparaginase (L-ASNase) is a chemotherapy agent depriving cancer cells of asparagine/glutamine as essential amino acids, commonly used in acute lymphoblastic leukemia, but underexplored in solid tumors.
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This study investigates combined L-ASNase and ionizing radiation (IR) effects across in vitro solid tumor models, quantifying synergy through proliferation and colony formation assays.... -
LUCIO FREGONESE
The research examines the strategies followed by Alessandro Volta to define and measure the "force" of electricity around the late 1780s, when both aspects—conceptual definition and quantitative experimental measurement—had not yet found (and will not for various decades find) a clear and coherent formulation. Not dissimilar to what happens in similar situations today, Volta very ably...
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ISABELLA GUARDAMAGNA
Ionizing radiation (IR) is an excellent probe to elicit a biological response and study the molecular mechanisms of DNA damage and repair in human cells, with implications in radiation protection and optimization of its medical use. This work focuses on γH2AX, a widely-used DNA damage marker, analyzing its induction, kinetics, and persistence in three cell lines with different...
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RICCARDO SCAGLIONI, ROBERTO MASTROFRANCESCO
The vast disparity between the LHC collision rate (∼40 MHz) and data storage capacity (∼1 kHz) forces the ATLAS Trigger to implement stringent cuts on high transverse momentum. These restrictions, such as the prescale on single-jet triggers severely limit physics sensitivity and discard many low-mass events (e.g., dijet below 1 TeV).
To recover these signatures, ATLAS implemented the...
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