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Congresso di Dipartimento e della Sezione INFN di Pavia

17–18 Feb 2026
Europe/Rome timezone

Biomedical Applications of Magnetic Nanoparticles: From Magnetic Fluid Hyperthermia to Quantitative Susceptibility Mapping

Not scheduled
1h 30m

Speaker

Francesca Brero (Physics Department, University of Pavia and INFN, Pavia Section)

Description

Magnetic nanoparticles (MNPs) are widely used in biomedical applications, including their role as hyperthermic agents for tumor treatment via Magnetic Fluid Hyperthermia (MFH) and as tracers in Quantitative Susceptibility Mapping (QSM).
In MFH, MNPs exposed to an alternating magnetic field generate localized heat within pathological tissues, enabling targeted thermal therapy. QSM is an advanced Magnetic Resonance Imaging (MRI) post-processing technique that reconstructs spatial maps of tissue magnetic susceptibility from phase data by solving an inherently ill-posed inverse problem.
Our research group investigates hyperthermia treatments combined with hadron therapy in three-dimensional tissue models, aiming to evaluate potential synergistic effects that could enhance therapeutic efficacy.
Within the QSM framework, we focus on tracking vesicles used as vehicles for targeted drug delivery in the treatment of neurodegenerative diseases. In this context, QSM enables the quantification of iron distribution, emerging as a powerful tool for mapping vesicle localization and concentration.

Primary authors

Francesca Brero (Physics Department, University of Pavia and INFN, Pavia Section) Dr Margherita Porru (Physics Department, University of Pavia and INFN, Pavia Section)

Co-authors

Alessandro Lascialfari (Physics Department, University of Pavia and INFN, Pavia Section) Prof. Angelica Facoetti (National Centre for Oncological Hadron Therapy, Pavia) Dr Anna Laurenzana (Department of Experimental and Clinical Biomedical Sciences, University of Florence) Prof. Camilla Recordati (Department of Veterinary Medicine and Animal Sciences, University of Milan and Mouse and Animal Pathology Laboratory (MAPLab), Fondazione Unimi) Dr Cecilia Anceschi (Department of Experimental and Clinical Biomedical Sciences, University of Florence) Dr Claudio Sangregorio (ICCOM-CNR and Department of Chemistry ‘Ugo Schiff’, University of Florence) Prof. Cristina Lenardi (Department of Physics “Aldo Pontremoli”, University of Milan and INFN Milan section) Francesco Orsini (Department of Physics “Aldo Pontremoli”, University of Milan and INFN Milan section) Prof. Ivan Veronese (Department of Physics “Aldo Pontremoli”, University of Milan and INFN Milan section) Dr Laura Sala (Department of Veterinary Medicine and Animal Sciences, University of Milan and Mouse and Animal Pathology Laboratory (MAPLab), Fondazione Unimi) Prof. Manuel Mariani (Physics Department, University of Pavia and INFN, Milano Section) Dr Marta Filibian (Biomedical Imaging Laboratory, Centro Grandi Strumenti, University of Pavia) Dr Martin Albino (ICCOM-CNR and Department of Chemistry ‘Ugo Schiff’, University of Florence) Paolo Arosio (Department of Physics “Aldo Pontremoli”, University of Milan and INFN Milan section) Prof. Pasquina Marzola (Department of Engineering for Innovation Medicine, University of Verona) Silvia Megalizzi (Department of Physics, University of Genova and Department of Medical Physics, Azienda Sociosanitaria Ligure 5, La Spezia) Prof. Vincenzo Amendola (Department of Chemical Sciences, University of Padova)

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